2019
- Tohma D, Tajima S, Kato F, Sato H, Kakisaka M , Hishiki K, Kataoka M, Takeyama H,
Lim C, Aida Y and Saijo M, An Estrogen Antagonist, Cyclofenil, Has Anti-Dengue Virus
Activity, Archives of Virology (in press) - Shinji Saito, Kaori Sano, Akira Ainai, Yuki Taga, Tomonori Ueno, Koshiro Tabata,
Kumpei Saito, Yuji Wada, Yuki Ohara, Haruko Takeyama, Takato Odagiri, Tsutomu
Kageyama, Kiyoko Ogawa-Goto, Pretty Multihartina, Vivi Setiawaty, Krisna Nur
Andriana Pangesti, Hideki Hasegawa, IgA tetramerization improves target breadth but
not peak potency of functionality of anti-influenza virus broadly neutralizing antibody.,
PLOS Pathogens, 2019 Jan 3, 15(1), e1007427‒23. - Hirokazu Taniguchi, Kumpei Tanisawa, Xiaomin Sun, Takafumi Kubo, Yuri Hoshino,
Masahito Hosokawa, Haruko Takeyama, Mitsuru Higuchi Effects of short-term
endurance exercise on gut microbiota in elderly men Physiological reports (in press) - Michihiro Ito, Kotaro Watanabe, Toru Maruyama, Tetsushi Mori, Kentaro Niwa, Seinen
Chow, Haruko Takeyama, “Enrichment of bacteria and alginate lyase genes potentially
involved in brown alga degradation in the gut of marine gastropods”, Scientific
reports, 9(1), 2129. - Takayuki Matsumura, Tadayoshi Ikebe, Koji Arikawa, Masahito Hosokawa, Michio Aiko,
Aoi Iguchi, Ikuko Togashi, Sayaka Kai, Sakiko Ohara, Naoya Ohara, Makoto Ohnishi,
Haruo Watanabe, Kazuo Kobayashi, Haruko Takeyama, Sho Yamasaki, Yoshimasa
Takahashi, and Manabu Ato, “Sequential sensing by TLR2 and Mincle directs immature
myeloid cells to protect against invasive group A streptococcal infection in mice”, Cell
Reports, 2019 April 9 - Kazutaka Terahara, Ryutaro Iwabuchi, Masahito Hosokawa, Yohei Nishikawa, Haruko
Takeyama, Yoshimasa Takahashi, Yasuko Tsunetsugu-Yokota, “A CCR5+ memory
subset within HIV-1-infected primary resting CD4+ T cells is permissive for replicationcompetent,
latently infected viruses in vitro”. BMC Research Notes. 29 April 2019 - Kenshi Yaginuma, Wataru Aoki, Natsuko Miura, Yuta Ohtani, Syunsuke Aburaya, Masato Kogawa,
Yohei Nishikawa, Masahito Hosokawa, Haruko Takeyama, Mitsuyoshi Ueda. “High-throughput
identification of peptide agonists against GPCRs by co-culture of mammalian reporter
cells and peptide-secreting yeast cells using droplet microfluidics”, Sci rep. 2019 July 29 - Yu Adachi, Keisuke Tonouchi, Arnone Nithichanon, Masayuki Kuraoka, Akiko Watanabe,
Ryo Shinnakasu, Hideki Asanuma, Akira Ainai, Yuhsuke Ohmi, Takuya Yamamoto, Ken Ishii,
Hideki Hasegawa, Haruko Takeyama, Ganjana Lertmemongkolchai, Tomohiro Kurosaki, Manabu Ato,
Garnett Kelsoe, and Yoshimasa Takahashi, “Exposure of an occluded hemagglutinin epitope drives
selection of a class of cross-protective influenza antibodies”. Nature Communications.
2018
- Iwabuchi R, Ikeno S, Kobayashi-Ishihara M, Takeyama H, Ato M, Tsunetsugu-Yokota Y
and Terahara K, Introduction of Human Flt3-L and GM-CSF into Humanized Mice
Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the
Development of Foxp3+CD4+ T Cells., Front. Immunol., 2018 May 28, 9:1042. doi:
10.3389/fimmu.2018.01042 - Omura N, Yoshikawa T, Fujii H, Shibamura M, Inagaki T, Kato H, Egawa K, Harada S,
Yamada S, Takeyama H and Saijo M, A Novel System for Constructing a Recombinant
Highly-Attenuated Vaccinia Virus Strain (LC16m8) Expressing Foreign Genes and Its
Application for the Generation of LC16m8-Based Vaccines against Herpes Simplex
Virus, Japanese Journal of Infectious Diseases, 2018 May 24, 71(3), 229‒233. - Mori T, Cahn JKB, Wilson MC, Meoded RA, Wiebach V, Martinez AFC, Helfrich EJN,
Albersmeier A, Wibberg D, twyler S, Keren R, Lavy A, Rckert C, Ilan M, Kalinowski J,
Matsunaga S, Takeyama H and Piel J. Proc Natl Acad Sci U S A. 2018 Feb 8. pii:
201715496. doi: 10.1073/pnas.1715496115. - Kogawa M, Hosokawa M, Nishikawa Y, Mori K and Takeyama H. Obtaining high-quality
draft genomes from uncultured microbes by cleaning and co-assembly of single-cell
amplified genomes. Sci Rep. 2018 Feb 1. 8(1):2059. doi: 10.1038/s41598-018-20384-
3. - Chung J, Wang X, Maruyama T, Ma Y, Kim M, Zhang X, Mez J, Sherva R, Takeyama H,
Lunetta KL, Farrer LA and Jun G, Genome-wide association study of Alzheimer disease
endophenotypes at preclinical stages., Alzheimer’s and Dementia, 2018 May,
14(5):623-633. doi: 10.1016/j.jalz.2017.11.006 - Kashima Y, Suzuki A, Liu Y, Hosokawa M, Matsunaga H, Shirai M, Arikawa K, Sugano S,
Kohno T, Takeyama H, Tsuchihara K and Suzuki Y, (2018). Combinatory use of distinct
single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome
response., Sci Rep, 2018 Feb 22, 8(1):3482. doi: 10.1038/s41598-018-21161-y. - Inagaki T, Satoh M, Fujii H, Yamada S, Shibamura M, Yoshikawa T, Harada S,
Takeyama H, Saijo, M. (2018). Acyclovir Sensitivity and Neurovirulence of Herpes
Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase
Gene, Which Were Detected in the Patients with Intractable Herpes Simplex
Encephalitis Previously Reported. Japanese journal of infectious diseases, JJID-2018.
2017
- Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H;
Alzheimer’s Disease Neuroimaging Initiative., Lunetta KL, Farrer LA, Jun GR. Genomewide
association study of Alzheimer’s disease endophenotypes at prediagnosis stages.
Alzheimers Dement. 2017 Dec 20. pii: S1552-5260(17)33842-6. doi:
10.1016/j.jalz.2017.11.006. - Moriyama M, Takeyama H, Hasegawa H, Ichinohe T. Induction of lung CD8(+) T cell
responses by consecutive inoculations of a poly(I:C) influenza vaccine. Vaccine. 2017
Dec 4. 35(48 Pt B):6620-6626. doi: 10.1016/j.vaccine.2017.10.038. - Maekawa S, Byadgi O, Chen YC, Aoki T, Takeyama H, Yoshida T, Hikima JI, Sakai M,
Wang PC, Chen SC. Transcriptome analysis of immune response against Vibrio
harveyi infection in orange-spotted grouper (Epinephelus coioides). Fish Shellfish
Immunol. 2017 Nov. 70:628-637. doi: 10.1016/j.fsi.2017.09.052. - Teru Y, Hikima JI, Kono T, Sakai M, Takano T, Hawke JP, Takeyama H, Aoki T. Whole-
Genome Sequence of Photobacterium damselae subsp. piscicida Strain 91-197,
Isolated from Hybrid Striped Bass (Morone sp.) in the United States. Genome
Announc. 2017 Jul 20. 5(29). pii: e00600-17. doi: 10.1128/genomeA.00600-17. - Hosokawa M, Nishikawa Y, Kogawa M, Takeyama H. Massively parallel whole genome
amplification for single-cell sequencing using droplet microfluidics. Sci Rep. 2017 Jul
12. 7(1):5199. doi: 10.1038/s41598-017-05436-4. - Yoda T, Hosokawa M, Takahashi K, Sakanashi C, Takeyama H, Kambara H. Sitespecific
gene expression analysis using an automated tissue micro-dissection
punching system. Sci Rep. 2017 Jun 28. 7(1):4325. doi: 10.1038/s41598-017-04616-
6. - Aoki T, Teru Y, Morimoto N, Kono T, Sakai M, Takano T, Hawke JP, Fukuda Y,
Takeyama H, Hikima JI. Complete Genome Sequence of Photobacterium damselae
subsp. piscicida Strain OT-51443 Isolated from Yellowtail (Seriola quinqueradiata) in
Japan. Genome Announc. 2017 May 25. 5(21). pii: e00404-17. doi:
10.1128/genomeA.00404-17. - Loch G, Zinke I, Mori T, Carrera P, Schroer J, Takeyama H, Hoch M. Antimicrobial
peptides extend lifespan in Drosophila. PLoS One. 2017 May 17. 12(5):e0176689. doi:
10.1371/journal.pone.0176689. - Wada Y, Nithichanon A, Nobusawa E, Moise L, Martin WD, Yamamoto N, Terahara K,
Hagiwara H, Odagiri T, Tashiro M, Lertmemongkolchai G, Takeyama H, De Groot AS,
Ato M, Takahashi Y. A humanized mouse model identifies key amino acids for low
immunogenicity of H7N9 vaccines. Sci Rep. 2017 Apr 28. 7(1):1283. doi:
10.1038/s41598-017-01372-5. - Hikima JI, Ando M, Hamaguchi HO, Sakai M, Maita M, Yazawa K, Takeyama H, Aoki T.
On-site Direct Detection of Astaxanthin from Salmon Fillet Using Raman
Spectroscopy. Mar Biotechnol (NY). 2017 Apr. 19(2):157-163. doi: 10.1007/s10126-
017-9739-7. - Omura N, Fujii H, Yoshikawa T, Yamada S, Harada S, Inagaki T, Shibamura M,
Takeyama H, Saijo M. Association between sensitivity of viral thymidine kinaseassociated
acyclovir-resistant herpes simplex virus type 1 and virulence. Virol J. 2017
Mar 21. 14(1):59. doi: 10.1186/s12985-017-0728-2. - Yoda T, Tanabe M, Tsuji T, Yoda T, Ishino S, Shirai T, Ishino Y, Takeyama H, Nishida H.
Exonuclease processivity of archaeal replicative DNA polymerase in association with
PCNA is expedited by mismatches in DNA. Sci Rep. 2017 Mar 16. 7:44582. doi:
10.1038/srep44582. - Maruyama T, Mori T, Yamagishi K, Takeyama H. SAG-QC: quality control of single
amplified genome information by subtracting non-target sequences based on
sequence compositions. BMC Bioinformatics. 2017 Mar 4. 18(1):152. doi:
10.1186/s12859-017-1572-5. - Naoko Takamizawa , S. Yamashita, N. Suzuki, K. Yamamoto, Haruko Takeyama,
Kazunaga Yazawa, T Takara, The impact of Uva tea extract capsule consumption on
psychological stress: A randomized, double-blind, placebo-controlled, crossover trial,
Japanese Pharmacology and Therapeutics, 46(12),2018. 1
2016
- Tsunetsugu-Yokota Y, Kobayahi-Ishihara M, Wada Y, Terahara K, Takeyama H,
Kawana-Tachikawa A, Tokunaga K, Yamagishi M, Martinez JP, Meyerhans A.
Homeostatically Maintained Resting Naive CD4(+) T Cells Resist Latent HIV
Reactivation. Front Microbiol. 2016 Dec 1. 7:1944. - Saga R, Fujimoto A, Watanabe N, Matsuda M, Hasegawa M, Watashi K, Aizaki H,
Nakamura N, Tajima S, Takasaki T, Konishi E, Kato T, Kohara M, Takeyama H, Wakita
T, Suzuki R. Bivalent vaccine platform based on Japanese encephalitis virus (JEV)
elicits neutralizing antibodies against JEV and hepatitis C virus. Sci Rep. 2016 Jun 27.
6:28688. doi: 10.1038/srep28688. - Brandstatter O, Schanz O, Vorac J, Konig J, Mori T, Maruyama T, Korkowski M,
Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H,
Weighardt H, F ﾃｶrster I. Balancing intestinal and systemic inflammation through cell
type-specific expression of the aryl hydrocarbon receptor repressor. Sci Rep. 2016
May 17. 6:26091. doi: 10.1038/srep26091. - Mori T, Takahashi M, Tanaka R, Miyake H, Shibata T, Chow S, Kuroda K, Ueda M,
Takeyama H. Falsirhodobacter sp. alg1 Harbors Single Homologs of Endo and Exo-
Type Alginate Lyases Efficient for Alginate Depolymerization. PLoS One. 2016 May 13.
11(5):e0155537. doi: 10.1371/journal.pone.0155537. - Moriyama M, Chen IY, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H,
Ichinohe T. The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are
Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1 ﾎｲ
Secretion. J Virol. 2016 Mar 28. 90(8):4105-14. doi: 10.1128/JVI.00120-16. - Saito S, Ainai A, Suzuki T, Harada N, Ami Y, Yuki Y, Takeyama H, Kiyono H, Tsukada H,
Hasegawa H. The effect of mucoadhesive excipient on the nasal retention time of and
the antibody responses induced by an intranasal influenza vaccine. Vaccine. 2016 Feb
24. 34(9):1201-7. doi: 10.1016/j.vaccine.2016.01.020. - Hikima J, Sakai M, Aoki T, Takeyama H, Hawke J, Mori K, Tashiro K, Kuhara S. Draft
Genome Sequence of the Fish Pathogen Mycobacterium pseudoshottsii Strain
JCM15466, a Species Closely Related to M.ﾂ marinum. Genome Announc. 2016 Feb
11. 4(1). pii: e01630-15. doi: 10.1128/genomeA.01630-15. - Mori T, Iwamoto K, Wakaoji S, Araie H, Kohara Y, Okamura Y, Shiraiwa Y, Takeyama H.
Characterization of a novel gene involved in cadmium accumulation screened from
sponge-associated bacterial metagenome. Gene. 2016 Feb 1. 576(2 Pt 1):618-25. doi:
10.1016/j.gene.2015.10.018.
2015
- Lai HC, Ng TH, Ando M, Lee CT, Chen IT, Chuang JC, Mavichak R, Chang SH, Yeh MD,
Chiang YA, Takeyama H, Hamaguchi HO, Lo CF, Aoki T, Wang HC. Pathogenesis of
acute hepatopancreatic necrosis disease (AHPND) in shrimp. Fish Shellfish Immunol.
2015 Dec. 47(2):1006-14. doi: 10.1016/j.fsi.2015.11.008. - Nishikawa Y, Hosokawa M, Maruyama T, Yamagishi K, Mori T, Takeyama H.
Monodisperse Picoliter Droplets for Low-Bias and Contamination-Free Reactions in
Single-Cell Whole Genome Amplification. PLoS One. 2015 Sep 21. 10(9):e0138733.
doi: 10.1371/journal.pone.0138733. - Ueoka R, Uria AR, Reiter S, Mori T, Karbaum P, Peters EE, Helfrich EJ, Morinaka BI,
Gugger M, Takeyama H, Matsunaga S, Piel J. Metabolic and evolutionary origin of
actin-binding polyketides from diverse organisms. Nat Chem Biol. 2015 Sep.
11(9):705-12. doi: 10.1038/nchembio.1870. - Ohmori M, Haruta K, Kamimura S, Koike H, Uchida T, and Takeyama H. A simple
method for nanobubble generation and stability of the bubbles. Journal of
Experimental Biology. 2015 Aug. 15(1):41-44. - Nurdiani D, Ito M, Maruyama T, Terahara T, Mori T, Ugawa S, Takeyama H. Analysis of
bacterial xylose isomerase gene diversity using gene-targeted metagenomics. J Biosci
Bioeng. 2015 Aug. 120(2):174-80. doi: 10.1016/j.jbiosc.2014.12.022. - Hosokawa M, Hoshino Y, Nishikawa Y, Hirose T, Yoon DH, Mori T, Sekiguchi T, Shoji S,
Takeyama H. Droplet-based microfluidics for high-throughput screening of a
metagenomic library for isolation of microbial enzymes. Biosens Bioelectron. 2015
May 15. 67:379-85. doi: 10.1016/j.bios.2014.08.059. - Nishida H, Kajisa T, Miyazawa Y, Tabuse Y, Yoda T, Takeyama H, Kambara H, Sakata T.
Self-oriented immobilization of DNA polymerase tagged by titanium-binding peptide
motif. Langmuir. 2015 Jan 20. 31(2):732-40. doi: 10.1021/la503094k.